<p>Spider toxins of the CSTX family are ion channel toxins containing an inhibitor cystine knot structural motif or Knottin scaffold (http://knottin.cbs.cnrs.fr). The four disulphide bonds present in the CSTX spider toxin family are arranged in the following pattern: 1-4, 2-5, 3-8 and 6-7. </p><p>This family includes: </p><ul><li> <taxon tax_id="6928">Cupiennius salei</taxon> (Wandering spider) toxin CSTX-1 and its proteolytic products CSTX-2a and CSTX-2b [<cite idref="PUB00033816"/>]. </li><li>C. salei (Wandering spider) CSTX-9 [<cite idref="PUB00033817"/>]. </li><li>C. salei (Wandering spider) CSTX-13, a neurotoxic enhancer. In contrast to CSTX-1 and CSTX-9, CSTX-13 is a two-chain peptide with two interchain and two intrachain disulphide bridges [<cite idref="PUB00033818"/>]. </li></ul> Spider toxin CSTX, Knottin scaffold conserved site